Odessa is a census-designated place in Odessa Township, Buffalo County, Nebraska, United States. It is part of the Kearney, Nebraska Micropolitan Statistical Area. The population of the CDP was 130 at the 2010 census.It was named after Odessa, in Ukraine.Odessa is located in southwestern Buffalo County along U.S. Route 30, 9 miles west of Kearney, the county seat. It is 6 miles west to Elm Creek via US 30. Interstate 80 passes to the south of Odessa, with access via Exit 263.According to the United States Census Bureau, the Odessa CDP has a total area of 1.8 square miles, all of it land.